Insulin-Like Growth Factor 1 (IGF-1) — (see also sh-Oligopeptide-2 or rh-Oligopeptide-2) may play an important role in prevention of facial aging. Because it is the primary growth factor in the ability of cells to grow and reproduce, it may be the most valuable for its anti-aging and regenerative effects. IGF-1 possesses the ability to stimulate both epithelial cells and fibroblasts to increase proliferation rates, promoting keratinocyte cellular repair and increasing collagen production. IGF-1 may have a role in delaying the accumulation of skin wrinkles by inhibition of collagenases (enzymes that break the peptide bonds in collagen), and reducing apoptosis (programmed cell death). Results of a study on 63 healthy volunteers, summarized in the (September 2015 - Volume 12 - Issue 3 - pg. 174-179) Journal of the Egyptian Women’s Dermatologic Society,” showed that serum level of IGF-1 decreased with increasing chronological aging, facial aging and photoaging. Serum level of IGF-1 was significantly higher in patients with a negative history of excessive sun exposure.